Grupo de Pesquisa

Grupo de Bioinformática Estrutural | UFRGS

Instituição

Universidade Federal do Rio Grande do Sul, Centro de Biotecnologia

Ano de Formação

1998

Líder(es)

Prof. Dr. Hugo Verli

Site

E-mail

[email protected]

Sobre o Grupo

Linhas de Pesquisa

Estrutura 3D de carboidratos, polissacarídeos, glicolipídeos e glicoproteínas
Aspectos moleculares da atividade de compostos anticoagulantes
Aspectos conformacionais e funcionais de proteínas
Análise conformacional de compostos bioativos

Principais Resultados

Artigos em revistas científicas:

Arantes, P.R.; Sachett, L.G.; Graebin, C.S.; Verli, H.: Conformational Characterization of Ipomotaosides and Their Recognition by COX-1 and 2. Molecules, 2014, 19, 5421-5433.http://10.3390/molecules19045421

Pedebos, C.; Pol-Fachin, L.; Pons, R.; Teixeira, C.V.; Verli, H.: Atomic Model and Micelle Dynamics of QS-21 Saponin. Molecules, 2014, 19, 3744-3760.http://dx.doi.org/10.3390/molecules19033744

Virgens, M.Y.; Pol-Fachin, L.; Verli, H.; Saraiva-Pereira, M.L.: Effects of glycosylation and pH conditions in the dynamics of human arylsulfatase A. J. Biomol. Struct. Dyn., 2014,32, 567-579. http://dx.doi.org/10.1080/07391102.2013.780982

Martinelli, A.H.; Kappaun, K.; Ligabue-Braun, R.; Defferrari, M.S.; Piovesan, A.R.; Stanisçuaski, F.; Demartini, D.R.; Dal Belo, C.A.; Almeida, C.G.; Follmer, C.; Verli, H.; Carlini, C.R.; Pasquali, G.: Structure-function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease. Biochim. Biophys. Acta, 2014, 1840, 935-944. http://dx.doi.org/10.1016/j.bbagen.2013.11.010

Pol-Fachin, L.; Verli, H.: Structural glycobiology of heparin dynamics on the exosite 2 of coagulation cascade proteases: Implications for glycosaminoglycans antithrombotic activity. Glycobiol., 2014, 24, 97-105. http://dx.doi.org/10.1093/glycob/cwt095

Córdula, C.R.; Lima, M.A.; Shinjo, S.K.; Gesteira, T.F.; Pol-Fachin, L.; Coulson-Thomas, V.J.; Verli, H.; Yates, E.A.; Rudd, T.R.; Pinhal, M.A.; Toma, L.; Dietrich, C.P.; Nader, H.B.; Tersariol, I.L: On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+. Mol. Biosyst.,2014, 10, 54-64. http://dx.doi.org/10.1039/c3mb70370c

Ligabue-Braun, R.; Andreis, F.C.; Verli, H.; Carlini, C.R.: 3-to-1: unraveling structural transitions in ureases. Naturwissenschaften, 2013, 100, 459-467.  http://dx.doi.org/10.1007/s00114-013-1045-2

Chiodi, C.G.; Verli, H.: Structural characterization of NETNES glycopeptide fromTrypanosoma cruzi. Carbohydr. Res., 2013, 373, 28-34.http://dx.doi.org/10.1016/j.carres.2013.03.010

Fernandez, P.V.; Quintana, I.; Cerezo, A.S.; Caramelo, J.J.; Pol-Fachin, L.; Verli, H.; Estevez, J.M.; Ciancia, M.: Anticoagulant Activity of a Unique Sulfated Pyranosic (1→3)-β-L-Arabinan through Direct Interaction with Thrombin. J. Biol. Chem., 2013, 288, 223-233. http://dx.doi.org/10.1074/jbc.M112.386441

Ligabue-Braun, R.; Real-Guerra, R.; Carlini, C.R.; Verli, H.: Evidence-based docking of the urease activation complex. J. Biom. Struct. Dyn., 2013, 31, 854-861.http://dx.doi.org/10.1080/07391102.2012.713782

Dahmer, T.; Berger, M.; Barlette, A.G.; Reck, J.; Segalin, J.; Verza, S.; Ortega, G.G.; Gnoatto, S.C.B.; Guimarães, J.A.; Verli, H.; Gosmann, G.: Antithrombotic Effect of Chikusetsusaponin IVa Isolated from (Maté). J. Med. Food, 2012, 15, 1073-1080.http://dx.doi.org/10.1089/jmf.2011.0320

Danuello, A.; Romeiro, N.C.; Giesel, G.M.; Pivatto, M.; Viegas Junior, C.; Verli, H.; Barreiro, E.J.; Fraga, C.A.M.; Castro, N.G.; Bolzani, V.S.: Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors.J. Braz. Chem. Soc., 2012, 23, 163-170. http://dx.doi.org/10.1590/S0103-50532012000100023

Ligabue-Braun, R.; Verli, H.; Carlini, C.R.: Venomous mammals: A review. Toxicon, 2012,59, 680-695. http://dx.doi.org/10.1016/j.toxicon.2012.02.012

Pedebos, C.; Pol-Fachin, L.; Verli, H.: Unrestrained Conformational Characterization ofStenocereus eruca Saponins in Aqueous and Nonaqueous Solvents. J. Nat. Prod., 2012,75, 1196-1200. http://dx.doi.org/10.1021/np3000393

Pol-Fachin, L.; Rusu, V.H.; Verli, H.; Lins, R.D.: GROMOS 53A6GLYC, an improved force field for hexopyranose-based carbohydrates. J. Chem. Theory Comp., 2012, 8, 4681-4690. http://dx.doi.org/10.1021/ct300479h

Pol-Fachin, L.; Verli, H.: Structural glycobiology of the major allergen of Artemisia vulgarispollen, Art v 1: O-glycosylation influence on the protein dynamics and allergenicity.Glycobiology, 2012, 22, 817-825. http://dx.doi.org/10.1093/glycob/cws056